Adiponectin levels and their association with obesity and type 2 diabetes mellitus

Abstract

Background: Adipose tissue metabolism has become area of research specially in obesity and its correlation with diabetes. It is now widely acknowledged that in addition to its conventional job as a store of energy, adipose tissue is a vital and extremely active endocrine organ that generates a range of hormones and other chemicals that are crucial for controlling insulin sensitivity and other physiological functions. This study looked into the connection between type 2 diabetes mellitus (T2DM), obesity, and adiponectin levels. Materials and Methods: Researchers recruited 120 participants and divided them into four groups: control, obese non-diabetic, diabetic with normal BMI, and obese diabetic. Serum adiponectin levels, HbA1c, postprandial blood glucose, and fasting blood glucose were measured from blood samples. In order to determine BMI and the waist-to-hip ratio, measurements of height, weight, waist, and hip circumference were taken as well. Results: The study found that adiponectin levels were significantly lower in all obese and diabetic groups compared to the control group (5.3±0.64 ng/ml, 6.11±1.09 ng/ml, 5.2±0.75 ng/ml and 7.99±2.5 ng/ml respectively). A negative correlation was observed between adiponectin levels and both BMI and HbA1c. These findings suggest a link between low adiponectin, obesity, and T2DM. Conclusion: This study highlights the potential role of adiponectin in understanding the development of T2DM in obese individuals. Further research on the mechanisms underlying this relationship may lead to novel therapeutic targets for obesity and T2DM.