E-cadherin expression – Significance in gastric carcinoma

Abstract

Introduction: Gastric carcinoma is aggressive cancer with poor prognosis. E-cadherin is 120 kD calcium mediated transmembrane glycoprotein that forms the cell adhesion molecule which maintains the integrity of epithelial cells by keeping it cohesive. E-cadherin down regulation in gastric cancer is of great significance in the dissociation of epithelial cells, alteration of tumor microenvironment, invasion, tumor genesis and metastasis. 
Aims and Objective: To study the E-cadherin expression in gastric carcinoma and to correlate with the existing clinical and pathological parameters.