Ondasetron and its effects on haemodynamics during LSCS under regional anaesthesia- A Randomized double blind controlled trial

Abstract

Introduction: Subarachnoid block (SAB) is also known as the method of choice of anaesthesia for lower segment caesarean section. The most common complications associated with it include hypotension and bradycardia. Ondansetron, now days is emerging as an effective alternative for the prevention of spinal induced hypotension in elective LSCS patients.
Aims & Materials and Methods: Our aim was to analyse & study the effect of Ondansetron 6mg I.V. on hemodynamics in lower segment caesarean section (LSCS) under regional anaesthesia. Study was conducted on a total of 60 parturients divided into 2 groups (Group I & Group II) scheduled for elective lower segment cesarean sections under Subarachnoid block.
Results: Comparison of mean heart rate between the Group I and Group II was found to be statistically not significant (p>0.05) at all the time intervals. The difference was found to be statistically significant (p=0.001), showing significantly higher intraoperative fluid requirement in Group II in comparison to Group I.
Conclusion: We observed that ondansetron 6mg I.V. given as a premedication 15 minutes before the administration of SAB resulted in a lesser incidence of hypotension following SAB.